Your enquiry0Metabolic research
RESEARCH USE ONLYLY3298176, LY-3298176
Tirzepatide is a lipid-modified peptide that activates GIP and GLP-1 receptors, linking incretin signaling with glucose-dependent insulin secretion and energy-balance research. Select your format and quantity for pricing, batch availability and lead time.
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ABOUT THE MATERIAL
Identity, scientific context and the details that distinguish this entry.
Tirzepatide is a lipid-modified peptide that activates GIP and GLP-1 receptors, linking incretin signaling with glucose-dependent insulin secretion and energy-balance research.[Sources]
Also designated LY3298176, it combines two receptor activities in one molecule. Receptor profiling distinguishes cAMP production, β-arrestin recruitment and receptor internalization, providing a detailed basis for comparison with selective GLP-1 agonists.
At GLP-1R, tirzepatide favors cAMP signaling relative to β-arrestin recruitment in the cited assays. Receptor abundance, exposure and the measured pathway are therefore important comparison variables.
A CLOSER LOOK
Read each finding with its study model and material identity.
The discovery study characterized GIPR and GLP-1R responses, glucose-dependent insulin secretion and metabolic endpoints in mice. The lipid-modified peptide was then evaluated in early clinical development. This sequence of experiments connects receptor pharmacology with integrated metabolic measurements.
Willard and colleagues compared cAMP production, β-arrestin recruitment and receptor trafficking. Tirzepatide showed stronger relative GIPR engagement and a GLP-1R signaling profile favoring cAMP over β-arrestin recruitment. These endpoint-specific responses explain the terms imbalanced and biased agonism.
PRODUCT DATA
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BATCH DOCUMENTATION
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BEFORE YOU ENQUIRE
At GLP-1R, tirzepatide favors cAMP signaling relative to β-arrestin recruitment in the cited assays. Receptor abundance, exposure and the measured pathway are therefore important comparison variables.
Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.
The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
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SOURCES
Content updated
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D'Alessio DA, Haupt A. 2018, DOI: 10.1016/j.molmet.2018.09.009
Receptor assays, islets, mice and early clinical development
Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW. 2020, DOI: 10.1172/jci.insight.140532
Receptor signaling and pancreatic islet experiments
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
EXPLORE THE CATALOGUE
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