Your enquiry0Metabolic research
RESEARCH USE ONLYAM833, NN0174-0833
Cagrilintide, also known as AM833, is a lipidated amylin analogue with activity at amylin and calcitonin receptor systems. Select your format and quantity for pricing, batch availability and lead time.
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ABOUT THE MATERIAL
Identity, scientific context and the details that distinguish this entry.
Cagrilintide, also known as AM833, is a lipidated amylin analogue with activity at amylin and calcitonin receptor systems.[Sources]
Amylin receptors consist of the calcitonin receptor associated with a receptor activity-modifying protein, or RAMP. Receptor composition and signaling readout help explain differences among cagrilintide, amylin and calcitonin analogues.
Association of the calcitonin receptor with different RAMPs creates amylin-receptor subtypes. Binding, cAMP signaling and receptor regulation should be compared within the same receptor configuration.
A CLOSER LOOK
Read each finding with its study model and material identity.
The AM833 study characterized binding, signaling and receptor regulation at calcitonin and RAMP-containing amylin receptor systems. Comparing these endpoints with amylin and calcitonin analogues reveals a distinct cagrilintide pharmacological profile within the calcitonin-family receptor framework.
Cagrilintide and KBP-336 were compared in receptor assays and rat metabolic models. Both activated amylin and calcitonin systems, with different relative receptor preferences. The study links receptor balance to specified body-weight and glucose endpoints in those models.
PRODUCT DATA
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BATCH DOCUMENTATION
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BEFORE YOU ENQUIRE
Association of the calcitonin receptor with different RAMPs creates amylin-receptor subtypes. Binding, cAMP signaling and receptor regulation should be compared within the same receptor configuration.
Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.
The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
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SOURCES
Content updated
Fletcher MM, Keov P, Truong TT, Mennen G, Hick CA, Zhao P, Furness SGB, Kruse T, Clausen TR, Wootten D, Sexton PM. 2021, DOI: 10.1124/jpet.121.000567
AM833 receptor pharmacology
Larsen AT, Mohamed KE, Sonne N, Bredtoft E, Andersen F, Karsdal MA, Henriksen K. 2022, DOI: 10.1016/j.biopha.2022.113842
Receptor assays and obese/diabetic rats
NCBI PubChem
Chemical identity reference
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
EXPLORE THE CATALOGUE
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