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Semaglutide is a modified GLP-1 receptor agonist used to study incretin signaling, glucose regulation and neural control of food intake. Select your format and quantity for pricing, batch availability and lead time.
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ABOUT THE MATERIAL
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Semaglutide is a modified GLP-1 receptor agonist used to study incretin signaling, glucose regulation and neural control of food intake.[Sources]
The molecular design includes Aib at position 8, Arg at position 34 and a fatty-acid-linked modification at Lys26. These changes are central to its enzymatic stability and albumin-binding properties.
Amino-acid substitutions and the Lys26-linked fatty-acid side chain alter degradation resistance and albumin interaction. Receptor signaling, albumin concentration and peptide integrity are relevant experimental variables.
A CLOSER LOOK
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Lau and colleagues describe sequence substitutions and Lys26-linked fatty-acid modification in semaglutide development. The experiments balance GLP-1 receptor activity, enzymatic stability and albumin affinity, connecting chemical design with measured pharmacological properties.
Rodent studies combined food-intake recording, peptide distribution and neuronal activation. Semaglutide accessed selected brain interfaces and GLP-1R populations associated with food intake and reward. Weight effects were associated with reduced intake without reduced energy expenditure; the distribution study distinguished accessible interfaces from general blood–brain-barrier passage.
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BEFORE YOU ENQUIRE
Amino-acid substitutions and the Lys26-linked fatty-acid side chain alter degradation resistance and albumin interaction. Receptor signaling, albumin concentration and peptide integrity are relevant experimental variables.
Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.
The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
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SOURCES
Content updated
Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. 2015, DOI: 10.1021/acs.jmedchem.5b00726
Peptide design and preclinical pharmacology
Gabery S, Salinas CG, Paulsen SJ, Ahnfelt-Rønne J, Alanentalo T, Baquero AF, Buckley ST, Farkas E, Fekete C, Frederiksen KS, Helms HCC, Jeppesen JF, John LM, Pyke C, Nøhr J, Lu TT, Polex-Wolf J, Prevot V, Raun K, Simonsen L, Sun G, Szilvásy-Szabó A, Willenbrock H, Secher A, Knudsen LB, Hogendorf WFJ. 2020, DOI: 10.1172/jci.insight.133429
Rodent brain mapping and feeding experiments
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
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