Your enquiry0Mitochondrial research
RESEARCH USE ONLYMitochondrial-derived peptide MOTS-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide involved in metabolic-stress signaling and communication between mitochondria and the nucleus. Select your format and quantity for pricing, batch availability and lead time.
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ABOUT THE MATERIAL
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MOTS-c is a 16-amino-acid mitochondrial-derived peptide involved in metabolic-stress signaling and communication between mitochondria and the nucleus.[Sources]
Its sequence is encoded within the mitochondrial 12S rRNA region. Published work links MOTS-c to the folate/purine pathway, AMPK-associated responses and stress-dependent nuclear translocation.
Under metabolic stress, the cited cell experiments observed AMPK-dependent nuclear translocation and interaction with stress-responsive transcriptional programs, including NRF2-associated antioxidant-response elements.
A CLOSER LOOK
Read each finding with its study model and material identity.
The discovery report identified a 16-residue peptide encoded within mitochondrial 12S rRNA. Cell studies linked MOTS-c to folate and purine metabolism and AMPK activation, followed by mouse metabolic experiments. These findings position MOTS-c within mitochondrial signaling and cellular energy adaptation.
Under metabolic stress, MOTS-c translocated to the nucleus through an AMPK-dependent process. Nuclear experiments identified associations with stress-responsive transcription factors and antioxidant-response-element-regulated genes, including NRF2-related programs. Localization and transcriptional response were measured as complementary endpoints.
Mouse experiments assessed physical performance, skeletal-muscle metabolism and adaptation to metabolic stress. The human portion measured endogenous MOTS-c before and after exercise. The publication therefore contains distinct animal intervention and human biomarker study designs.
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Under metabolic stress, the cited cell experiments observed AMPK-dependent nuclear translocation and interaction with stress-responsive transcriptional programs, including NRF2-associated antioxidant-response elements.
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The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
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SOURCES
Content updated
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, de Cabo R, Cohen P. 2015, DOI: 10.1016/j.cmet.2015.02.009
Cell metabolism and mouse metabolic models
Kim KH, Son JM, Benayoun BA, Lee C. 2018, DOI: 10.1016/j.cmet.2018.06.008
Cellular stress and nuclear-translocation experiments
Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. 2021, DOI: 10.1038/s41467-020-20790-0
Mouse interventions and human endogenous-peptide measurements
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
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