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ARA-290

Cibinetide, pHBSP, Helix B surface peptide

ARA-290, also known as cibinetide or pHBSP, is an 11-residue EPO-derived peptide studied in tissue-response and neuroinflammatory models. Select your format and quantity for pricing, batch availability and lead time.

CAS
1208243-50-8
Purity
>99%
Form
Lyophilized powder

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Specification
10 mg / vial
Sales unit
box
Packaging
10 vials / box
Selected SKURA10

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✓ Batch-linked records✓ Private-label support✓ Multiple formats✓ Research use only

ABOUT THE MATERIAL

Product overview

Identity, scientific context and the details that distinguish this entry.

ARA-290, also known as cibinetide or pHBSP, is an 11-residue EPO-derived peptide studied in tissue-response and neuroinflammatory models.[Sources]

The design mimics the aqueous surface of EPO helix B. Discovery experiments separated the tissue-response activity of this short peptide from the erythropoietic function of intact EPO.

Research variables

ARA-290 is a short surface-mimetic peptide rather than the full cytokine. The discovery study measured tissue-response endpoints and erythropoiesis separately.

A CLOSER LOOK

Mechanisms & published research

Read each finding with its study model and material identity.

01

Separating a helix-derived signal from erythropoiesis

EPO surface-derived peptides were assessed in cell and animal tissue-response models. An 11-residue helix-B surface mimetic retained tissue-response activity while erythropoietic activity was assessed separately. The study connects a defined structural motif with measured biological endpoints.

02

A small exploratory neuropathy trial

The exploratory randomized study enrolled 22 people with sarcoidosis-associated small-fiber-neuropathy symptoms. The SFNSL symptom score showed a between-group difference, while the BPI pain measure improved similarly in both groups. Reporting the scales separately preserves the findings of this small pilot study.

PRODUCT DATA

Specifications & identifiers

Product specifications and batch results are confirmed with your quotation and COA.

Product
ARA-290
CAS
1208243-50-8
Molecular formula
C₅₁H₈₄N₁₆O₂₁
Molecular weight
1257.3 Da
Form
Lyophilized powder
Amino-acid sequence
Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH

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BATCH DOCUMENTATION

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01

Batch COA

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02

HPLC / MS records

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03

SDS & storage information

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BEFORE YOU ENQUIRE

Common questions

How does ARA-290 differ from full-length EPO?

ARA-290 is a short surface-mimetic peptide rather than the full cytokine. The discovery study measured tissue-response endpoints and erythropoiesis separately.

How should storage and handling be confirmed?

Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.

How are catalogue specifications checked against a batch?

The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.

What information helps with a quotation?

Include the exact SKU, quantity in boxes, destination, desired timing and document requirements. State any label or packaging needs. Pricing, availability, lead time and document scope are confirmed in the quotation.

SOURCES

References & technical sources

Content updated

  1. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. ↗

    Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S, Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A. 2008, DOI: 10.1073/pnas.0805594105

    Cell and animal tissue-injury models

  2. Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study. ↗

    Heij L, Niesters M, Swartjes M, Hoitsma E, Drent M, Dunne A, Grutters JC, Vogels O, Brines M, Cerami A, Dahan A. 2012, DOI: 10.2119/molmed.2012.00332

    Pilot study in 22 patients with sarcoidosis-associated neuropathy

  3. Cibinetide, PubChem CID 91810664 ↗

    NCBI PubChem

    Pyroglutamyl peptide chemical identity

Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.

EXPLORE THE CATALOGUE

Related research materials

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