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RESEARCH USE ONLYThymosin Beta-4, Tβ4, Timbetasin
TB-500 in this catalogue is Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide involved in actin dynamics, cell migration and tissue-response research. Select your format and quantity for pricing, batch availability and lead time.
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ABOUT THE MATERIAL
Identity, scientific context and the details that distinguish this entry.
TB-500 in this catalogue is Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide involved in actin dynamics, cell migration and tissue-response research.[Sources]
The full-length, N-acetylated peptide binds monomeric G-actin and helps regulate the pool available for filament assembly. Its actin-binding region is part of a larger peptide structure with distinct N- and C-terminal domains.
This entry uses full-length 43-residue Thymosin Beta-4. The seven-residue region LKKTETQ is only part of that sequence. Full-length and fragment experiments address different materials and are cited separately.
A CLOSER LOOK
Read each finding with its study model and material identity.
Biochemical assays compared full-length 43-residue Thymosin Beta-4 with related peptides and fragments. Tβ4 sequestered monomeric G-actin at a 1:1 ratio and inhibited its polymerization under the tested conditions. Fragment comparisons identified the importance of sequence regions preceding residue 13.
Bock-Marquette and colleagues investigated full-length Tβ4 in cardiac-cell migration and survival models. The experiments linked tissue responses with PINCH/ILK/Akt-associated signaling. This provides a tissue-level complement to the biochemical work on actin binding.
PRODUCT DATA
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BATCH DOCUMENTATION
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BEFORE YOU ENQUIRE
This entry uses full-length 43-residue Thymosin Beta-4. The seven-residue region LKKTETQ is only part of that sequence. Full-length and fragment experiments address different materials and are cited separately.
Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.
The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
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SOURCES
Content updated
Hannappel E, Wartenberg F. 1993, DOI: 10.1515/bchm3.1993.374.1-6.117
Biochemical actin-sequestration experiments
Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. 2004, DOI: 10.1038/nature03000
Cardiac cells and mouse injury model; full-length thymosin β4
NCBI PubChem
Chemical identity and full-length peptide sequence
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
EXPLORE THE CATALOGUE
Explore related entries. Similar research contexts do not establish interchangeability.