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KPV

α-MSH(11-13), KPV tripeptide

KPV is the Lys-Pro-Val tripeptide studied in PepT1-mediated cellular uptake and inflammatory-signaling models. Select your format and quantity for pricing, batch availability and lead time.

CAS
67727-97-3
Purity
>99%
Form
Lyophilized powder

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2 options
Specification
5 mg / vial
Sales unit
box
Packaging
10 vials / box
Selected SKUKPV5

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Test method: HPLC. Catalogue specification. Confirm the supplied batch against its COA.

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✓ Batch-linked records✓ Private-label support✓ Multiple formats✓ Research use only

ABOUT THE MATERIAL

Product overview

Identity, scientific context and the details that distinguish this entry.

KPV is the Lys-Pro-Val tripeptide studied in PepT1-mediated cellular uptake and inflammatory-signaling models.[Sources]

The sequence corresponds to the C-terminal three residues of α-MSH. Published work follows peptide transport, NF-κB/MAPK-related responses and intestinal inflammatory markers.

Research variables

PepT1 is a di- and tripeptide transporter. The cited studies assess KPV uptake and compare inflammatory responses under different transporter-expression conditions.

A CLOSER LOOK

Mechanisms & published research

Read each finding with its study model and material identity.

01

PepT1 transport and inflammatory readouts

Dalmasso and colleagues measured KPV uptake through PepT1 in epithelial and immune cells. NF-κB/MAPK signaling and inflammatory mediator measurements were paired with mouse colitis experiments. Transporter expression and cellular uptake are central variables in this research framework.

02

Testing transporter dependence

The mouse study examined colitis-associated tumor formation under different PepT1-expression conditions. Responses to KPV differed in transporter-deficient animals. The model connects peptide transport with specified inflammatory and tumor-related endpoints in mice.

PRODUCT DATA

Specifications & identifiers

Product specifications and batch results are confirmed with your quotation and COA.

Product
KPV
CAS
67727-97-3
Molecular formula
C₁₆H₃₀N₄O₄
Molecular weight
342.44 Da
Form
Lyophilized powder
Amino-acid sequence
H-Lys-Pro-Val-OH
Terminal groups
Free N-terminus and C-terminal carboxylic acid; the formula and CAS refer to this free-acid peptide.

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BATCH DOCUMENTATION

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01

Batch COA

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02

HPLC / MS records

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03

SDS & storage information

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BEFORE YOU ENQUIRE

Common questions

What role does PepT1 have in KPV research?

PepT1 is a di- and tripeptide transporter. The cited studies assess KPV uptake and compare inflammatory responses under different transporter-expression conditions.

How should storage and handling be confirmed?

Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.

How are catalogue specifications checked against a batch?

The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.

What information helps with a quotation?

Include the exact SKU, quantity in boxes, destination, desired timing and document requirements. State any label or packaging needs. Pricing, availability, lead time and document scope are confirmed in the quotation.

SOURCES

References & technical sources

Content updated

  1. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. ↗

    Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. 2008, DOI: 10.1053/j.gastro.2007.10.026

    Intestinal/immune cells and mouse colitis models

  2. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model. ↗

    Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D. 2016, DOI: 10.1016/j.jcmgh.2016.01.006

    AOM/DSS mouse model and PepT1-deficient animals

  3. MSH(11–13), PubChem CID 125672 ↗

    NCBI PubChem

    Chemical identity reference

Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.

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