GHRH-derived peptide structure–activity research
Systematic GHRH(1–29) substitution studies measure how sequence affects pituitary GH-release activity. This is pathway and structure–activity background for the no-DAC peptide.
THE BATCHTIDE RANGEProduct packaging
Label detailsMinimum listed format shown
GH-axis research
RESEARCH USE ONLYCJC-1295 without DAC
Modified GRF(1–29), CJC-1295 without DAC
CJC-1295 without DAC is tetrasubstituted GRF(1–29) acetate, a 29-residue GHRH analogue without an albumin-reactive DAC group. Select your format and quantity for pricing, batch availability and lead time.
- CAS
- 863288-34-0
- Purity
- >99%
- Form
- Lyophilized powder
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2 options- Specification
- 5 mg / vial
- Sales unit
- box
- Packaging
- 10 vials / box
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✓ Batch-linked records✓ Private-label support✓ Multiple formats✓ Research use only
ABOUT THE MATERIAL
Product overview
Identity, scientific context and the details that distinguish this entry.
CJC-1295 without DAC is tetrasubstituted GRF(1–29) acetate, a 29-residue GHRH analogue without an albumin-reactive DAC group.[Sources]
The sequence contains D-Ala2, Gln8, Ala15 and Leu27 substitutions, a free N-terminus and an amidated C-terminus. These structural features define the no-DAC material used in GHRH-receptor research.
Research variables
Compare GHRH-receptor responses alongside peptide structure and albumin-conjugation behavior. The albumin-dependent exposure findings of DAC constructs apply to that structural design.
A CLOSER LOOK
Mechanisms & published research
Read each finding with its study model and material identity.
Structural comparison: the separate with-DAC construct
The CJC-1295 design uses a maleimide-containing modification to link the peptide covalently to albumin Cys34. The study combines conjugation chemistry with endocrine measurements. It specifically describes the albumin-reactive DAC construct used in prolonged-exposure research.
PRODUCT DATA
Specifications & identifiers
Product specifications and batch results are confirmed with your quotation and COA.
- Product
- CJC-1295 without DAC
- CAS
- 863288-34-0
- Molecular formula
- C₁₅₂H₂₅₂N₄₄O₄₂
- Molecular weight
- 3367.97 g/mol (peptide moiety)
- Form
- Lyophilized powder
- Salt form
- Acetate
- Amino-acid sequence
- H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
- Formula and MW basis
- Peptide moiety; acetate counter-ions and water are excluded.
- Measurement basis
- Net peptide weight
- Sequence modifications
- D-Ala2, Gln8, Ala15, Leu27; free N-terminus; C-terminal amide
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HPLC / MS records
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BEFORE YOU ENQUIRE
Common questions
How should no-DAC and with-DAC materials be compared?
Compare GHRH-receptor responses alongside peptide structure and albumin-conjugation behavior. The albumin-dependent exposure findings of DAC constructs apply to that structural design.
How should storage and handling be confirmed?
Use the specification and available safety or stability information for the offered lot, form and packaging. Request written conditions before ordering; literature alone does not establish a universal temperature, shelf life or reconstitution procedure.
How are catalogue specifications checked against a batch?
The displayed value is a catalogue specification. Assess the offered lot against its matching COA and method. Chromatographic purity, component content and biological activity are different measurements; confirm which results are available.
What information helps with a quotation?
Include the exact SKU, quantity in boxes, destination, desired timing and document requirements. State any label or packaging needs. Pricing, availability, lead time and document scope are confirmed in the quotation.
SOURCES
References & technical sources
Content updated
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. ↗
Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP. 2005, DOI: 10.1210/en.2004-1286
Albumin-conjugation chemistry, pituitary cells and rats
- Human growth hormone-releasing hormone hGHRH(1-29)-NH2: systematic structure-activity relationship studies. ↗
Cervini LA, Donaldson CJ, Koerber SC, Vale WW, Rivier JE. 1998, DOI: 10.1021/jm970618s
GHRH(1–29) analogue structure–activity assays
- Modified GRF(1–29) structure, PubChem CID 56841945 ↗
NCBI PubChem
Sequence-specific structure
Publications describe their own study materials and methods. They are distinct from BatchTide specifications and lot-release records. Materials listed here are for laboratory research only, not for human or veterinary use.
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